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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK2
All Species:
21.21
Human Site:
S209
Identified Species:
33.33
UniProt:
Q92630
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92630
NP_003574.1
601
66652
S209
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
Chimpanzee
Pan troglodytes
XP_509205
601
66595
S209
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
Rhesus Macaque
Macaca mulatta
XP_001117134
601
66643
S209
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
Dog
Lupus familis
XP_538273
601
66656
S209
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
Cat
Felis silvestris
Mouse
Mus musculus
Q5U4C9
599
66538
G232
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
Rat
Rattus norvegicus
Q4V8A3
586
65492
S218
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
L219
E
I
R
I
L
E
H
L
R
K
Q
D
R
D
N
Chicken
Gallus gallus
Q5ZIU3
526
59419
N206
R
K
Q
D
K
D
N
N
M
N
V
I
H
M
L
Frog
Xenopus laevis
NP_001088793
567
63329
A216
H
K
L
H
Q
H
L
A
V
K
M
V
R
N
E
Zebra Danio
Brachydanio rerio
NP_001038298
587
65453
S219
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
A263
E
Y
D
N
E
Q
G
A
Y
I
H
V
P
H
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023208
796
87422
S448
G
Y
D
D
E
N
G
S
Y
Q
L
V
V
H
D
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
V210
S
F
G
Q
V
V
K
V
Y
D
H
K
T
N
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
R147
V
V
A
I
K
V
I
R
S
I
N
K
Y
R
E
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
Y356
I
N
S
D
Y
I
L
Y
V
N
D
V
L
G
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
99.6
98.3
N.A.
97
59.7
N.A.
78.6
81.3
64.5
83.6
N.A.
43.3
N.A.
45.7
63.7
Protein Similarity:
100
98.8
99.8
99
N.A.
98.5
71.8
N.A.
83
84.5
75
89.8
N.A.
54.9
N.A.
55.6
73.5
P-Site Identity:
100
100
100
100
N.A.
13.3
26.6
N.A.
6.6
6.6
6.6
26.6
N.A.
60
N.A.
66.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
20
40
N.A.
20
20
26.6
40
N.A.
86.6
N.A.
73.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.3
27.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
36.6
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
0
14
0
0
0
0
14
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
40
47
27
7
0
0
0
7
7
7
0
7
47
% D
% Glu:
14
0
0
0
14
7
0
0
0
0
0
0
0
0
14
% E
% Phe:
0
7
0
0
0
0
7
0
14
0
0
0
0
0
0
% F
% Gly:
34
0
14
0
20
0
54
7
0
14
0
0
0
7
0
% G
% His:
7
0
0
7
0
7
7
0
0
0
14
0
7
40
0
% H
% Ile:
7
14
7
27
0
7
7
0
0
14
0
7
0
0
0
% I
% Lys:
0
27
0
7
14
14
7
0
0
14
0
20
0
7
0
% K
% Leu:
14
0
7
0
7
0
14
7
0
0
7
0
7
0
7
% L
% Met:
0
0
0
0
0
0
0
0
7
0
7
0
0
7
0
% M
% Asn:
0
7
0
7
0
7
7
7
0
14
7
0
0
14
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
34
0
0
% P
% Gln:
0
0
7
7
7
34
0
0
7
7
47
0
0
0
7
% Q
% Arg:
7
0
7
0
0
0
0
7
7
0
0
0
14
14
0
% R
% Ser:
7
0
7
0
0
7
0
47
7
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% T
% Val:
14
7
7
0
7
14
0
7
14
34
14
67
14
0
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
40
0
0
7
0
0
7
47
0
0
0
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _